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Contemplate prescribing naloxone, according to the affected person's threat aspects for overdose, such as concomitant usage of CNS depressants, a history of opioid use problem, or prior opioid overdose.

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Over the Element of the musculoskeletal process: muscle mass fasciculations, cramps, soreness in muscles and joints, swelling of joints, muscle mass stiffness, discomfort in back again and limbs. In several scenarios observed the development of spasm on the neck muscles and rhabdomyolysis.

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